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Off-label use for hyperbilirubinemia: Phenobarbital induces glucuronyl transferase and hepatic bilirubin-binding Y-protein to decrease serum bilirubin concentrationsObserve Closely (1)phenobarbital will minimize the extent or result of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Lack of, or decreased res